Estimation of flavonoids intake in adults has been important for the development of dietary recommendations and interventions for the prevention of weight gain and its. Methods and resultsqualitative and quantitative data on 383 polyphenol metabolites as described in 424. Phenol explorer, launched in 2009, is the only comprehensive webbased database on the content in foods of polyphenols, a major class of food bioactives that receive considerable attention due to. Flavanol compounds reported in the united states department of agriculture usda and phenolexplorer pe databases o oh aglycone structure1 compounds. Few retention factor databases have been developed for food nutrients. Here we report the third release of the database phenolexplorer 3. Provides data concerning polyphenols in foods, a major class of food bioactives. As described in previous studies with similar methodology, the polyphenol content of foods included in the ffq that could corresponded to several entries in the phenolexplorer database i. The 501 polyphenols with composition data are classified in 6 classes and 31 subclasses. Phenol explorer is offered to the public as a freely available resource. Databases like phenolexplorer and metlin will be two tools in order to measure the polyphenol intake accurately. To date, limited data exist on intake of polyphenols in populations.
As a member of the wwpdb, the rcsb pdb curates and annotates pdb data according to agreed upon standards. Phenol is also used as an organic solvent to dissolve other alcohols, chloroform and ether. Evaluation of urinary resveratrol as a biomarker of. Use the scrolling menu on the left to select one or several compound classes or subclasses. A computationally driven analysis of the polyphenol. Identification of the 100 richest dietary sources of polyphenols. The new update will allow polyphenol scientists to more accurately estimate. Therefore, in the current work, we have studied the coumarins that are present in food sources extracted from the phenolexplorer database in order to predict their clastogenic activity and identify the structureactivity relationships and genotoxic structural alerts using alternative methods in the field of computational toxicology. Dietary intake of 20 polyphenol subclasses in a cohort of.
Approaches to food varietal differentiation using accurate. Estimated dietary intake and major food sources of. The database was then queried for the presence of any of the 43 defined polyphenol substructures, obtained from 31 defined subclasses of polyphenols according. Phenol explorer is the first comprehensive database on polyphenol content in foods. Phenolexplorer is an openaccess web database on polyphenols, a major group ofphytochemicals abundant in plant foods. Use the scrolling menu on the left to select one or several food classes or subclasses. This new phenol explorer release will be made public by this summer. Phenol explorer is an openaccess web database on polyphenols, a major group ofphytochemicals abundant in plant foods. Phenol is used in the preparation of resins, dyes, explosives, lubricants, pesticides and plastics. The sensidyne gas detector tube system and phenol 0.
Contains all of the content values, foods, methods, and polyphenols present in version 1 of phenol explorer. The database was then queried for the presence of any of the 43 defined polyphenol substructures, obtained from 31 defined subclasses of polyphenols according to phenol explorer version 3. Phenolexplorer, launched in 2009, is the only freely available webbased database on the content of polyphenols in food and their in vivo metabolism and pharmacokinetics. Jun 17, 2015 polyphenols are plant secondary metabolites with a large variability in their chemical structure and dietary occurrence that have been associated with some protective effects against several chronic diseases. Phenol explorer is a comprehensive database on natural phenols and polyphenols including food composition, food processing, and polyphenol metabolites in human and. Phenolexplorer is a resource that includes retention factors on the class of dietary bioactives.
Search by structure, identifiers, properties, data sources, elements, lasso similarity. The current crosssectional analysis aimed at estimating dietary intakes of all currently known individual polyphenols. Contains all of the content values, foods, methods, and polyphenols present in version 1 of phenolexplorer. The database contains more than 35,000 content values for 500 different. For brevity and clarity, structures are drawn in a 2dimensional plane. The phenol explorer database and the usda database on flavonoids content were used.
Sep 16, 2014 rothwell ja, urpisarda m, botoordonez m, knox c, llorach r, eisner r, cruz j, neveu v, wishart d, manach c, andreslacueva c, scalbert a. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. Comparison of polyphenol intakes according to distinct. Use the textboxes below to filter on polyphenol name, molecular weight, chemical formula, and the number of associated foods and composition data.
Phenolexplorer is a major step forward in the development of databases on food constituents and the food metabolome. It includes weighed mean content values for 502 polyphenols in 452 foods and beverages, produced from more than 37 000 original composition data. This new technology delivers improved performance for challenging semivolatile analyses such as pahs, phenols, and amines. The database will contain additional information about polyphenols in foods cooked in different manners, so that you can check which amount of polyphenols you lose when boiling your vegetables. Oct 06, 20 phenol explorer, launched in 2009, is the only freely available webbased database on the content of polyphenols in food and their in vivo metabolism and pharmacokinetics. Use the textboxes below to filter on polyphenol name, molecular weight, chemical formula, and the number of associated.
Background plantbased diets have been linked to high diet quality and reduced risk of cardiovascular diseases. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Phenolexplorer is a comprehensive database on polyphenol content in foods. Use the textboxes below to filter on food common name, french name, botanical family, scientific name, and the number of associated compounds and composition data. Here we report the third release of the database phenol explorer 3. It is an aromatic compound classified as an alcohol. Peakviewis a software that will aid in finding the polyphenols at their designated molecular weight so that retention time can be found. A master list of polyphenols was created using peakview and phenolexplorer database. Phenol colorimetric gas detector tubes for detection of airborne gases and vapors colorimetric phenol 0. Data were collected to build a spectral database in order to identify spectral features of each family of phenolic compounds studied. Polyphenols natural phenols food databases biological databases biological database stubs. In an applied work of the phenolexplorer database, the richest sources of polyphenols were identified as various spices and dried herbs, cocoa products, some darkly coloured berries, some seeds flaxseed and nuts chestnut, hazelnut and some vegetables, including olive and artichoke perezjimenez et al. These data are derived from the systematic collection of more than 60,000 original content values found in more than 1,300 scientific. May 16, 20 the database will contain additional information about polyphenols in foods cooked in different manners, so that you can check which amount of polyphenols you lose when boiling your vegetables.
Rothwell we gratefully acknowledge danone research, the french national institute of cancer and the university of barcelona for financing the project. The database contains more than 35,000 content values for 500 different polyphenols in over 400 foods. A computationally driven analysis of the polyphenolprotein. Connect visual studio with mysql database using server. This is a repository copy of dietary intake of 20 polyphenol subclasses in a cohort of uk women.
Phenolexplorer is a comprehensive database on natural phenols and polyphenols including. These omic era databases are being developed to help researchers. Phenolexplorer is the first comprehensive database on polyphenol content in foods. This dualdistillation column system was designed by sabic to separate and purify up to 16 mthr of phenol from a complex mixture of hydrocarbons and water. Jan 08, 2010 phenol explorer is the first comprehensive database on polyphenol content in foods. Phenolexplorer is a comprehensive database on natural phenols and polyphenols including food composition, food processing, and polyphenol metabolites. All data are available using an open access userfriendly web interface. How to cite us phenolexplorer database on polyphenol. Mildly acidic, it requires careful handling because it can cause chemical burns. A number of databases on the plant metabolome describe the chemistry and biosynthesis of plant chemicals. Evidence for a protective effect of polyphenolscontaining.
Phenol is an organic compound that contains the hydroxyloh group attached to a benzene ring. The molecular formula of phenol is c6h6o, and it has a molecular weight of 94. Database on polyphenol content in foods phenolexplorer. Phenolexplorer, launched in 2009, is the only comprehensive webbased database on the content in foods of polyphenols, a major class of food bioactives that receive considerable attention due to. The agilent masshunter qualitative analysis software was used to search qtof lcms data of extracts of seven varieties of onions for matches with the flavonoid database. The 2 polyphenols with retention factor data are classified in 3 classes and 10 subclasses. This resource allows the filtering of information according to various criteria. Name of the repository software unknown versioning yes. Phenol is also a versatile precursor to a large collection of drugs, most notably aspirin but also many herbicides and pharmaceutical drugs. Food composition database microsoft access the complete food composition database, without the metabolism and retention factor components. Dietary intake of 20 polyphenol subclasses in a cohort of uk.
Polyphenols are plant secondary metabolites with a large variability in their chemical structure and dietary occurrence that have been associated with some protective effects against several chronic diseases. From the riochemical laboratories of the harvard medical school and oj the massachusetts general hospital, boston. France we carried out the expansion of the database phenol explorer 2. Phenol is a component in liquidliquid phenolchloroform extraction technique used in molecular biology for obtaining nucleic acids from tissues or cell culture samples. The 459 foods with composition data are classified in 9 classes and 67 subclasses. Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Phenolexplorer was the primary consulting database, because concentrations of all measured polyphenol classes are provided for each food and most of them are presented as glycosides and esters of compounds.
Use and redistribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material phenol explorer and the original publications see how to cite us. Development of polyphenol metabolites databases in. The phenolic compound spectra showed common spectral bands associated with aromatic sixmembered rings and phenol moieties. Use the textboxes below to filter on polyphenol name, process, and the number of associated foods and retention factor data. Important we ask that users who download significant portions of the database cite the phenolexplorer paper in any resulting publications. The health impact of plantbased diets might be partially explained by the concomitant intake of flavonoids. The rcsb pdb also provides a variety of tools and resources. Phenol is an aromatic organic compound with the molecular formula c 6 h 5 oh.
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